Yasushi Akahori

Yasushi Akahori, Ph,D.

Lecturer, Center for Comprehensive Cancer Immunotherapy, Mie University Graduate School of Medicine

Address

2-174, Edobashi, Tsu, Mie, 514-8507
Phone +59-231-5187, Fax +59-231-5276
Email: yakahori@clin.medic.mie-u.ac.jp

Profiles and Research Field

He has been engaged in antibody library construction, screening of antibodies that can recognize tumor surface antigens. Now his major work is to isolate pMHC recognizing antibody and construct CAR for cancer therapy.

Research title

Recent publications

  1. Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling. Yamamoto Y, Tsuzuki S, Akahori Y, Ukai Y, Sumitomo M, Murayama Y, Yamamoto K, Inaguma Y, Tokuda M, Abe A, Akatsuka Y, Emi N, Kurosawa Y. Cancer Sci. 2012 Feb;103(2):350-9. 
  2. Neutralizing anti-gH antibody of Varicella-zoster virus modulates distribution of gH and induces gene regulation, mimicking latency. Shiraki K, Daikoku T, Takemoto M, Yoshida Y, Suzuki K, Akahori Y, Okuno T, Kurosawa Y, Asano Y. J Virol. 2011 Aug;85(16):8172-80. 
  3. Selection and analysis of anti-cancer antibodies for cancer therapy obtained from antibody phage library. Kurosawa G, Sumitomo M, Ukai Y, Subere J, Muramatsu C, Eguchi K, Tanaka-Hashiba M, Sugiura M, Ando M, Sato N, Morita M, Inaba K, Morigaki S, Takasaki A, Akahori Y, Miyakawa S, Uyama I, Maeda K, Shiroki R, Hoshinaga K, Mizoguchi Y, Hattori Y, Sugioka A, Sugiura M, Kurosawa Y. Cancer Sci. 2011 Jan;102(1):175-81. 
  4. Methods for comprehensive identification of membrane proteins recognized by a large number of monoclonal antibodies. Kurosawa G, Sumitomo M, Akahori Y, Matsuda K, Muramatsu C, Takasaki A, Iba Y, Eguchi K, Tanaka M, Suzuki K, Morita M, Sato N, Sugiura M, Sugioka A, Hayashi N, Kurosawa Y. J Immunol Methods. 2009 Dec 31;351(1-2):1-12. 
  5. Characterization of neutralizing epitopes of varicella-zoster virus glycoprotein H. Akahori Y, Suzuki K, Daikoku T, Iwai M, Yoshida Y, Asano Y, Kurosawa Y, Shiraki K. J Virol. 2009 Feb;83(4):2020-4. 
  6. Isolation of antigen/antibody complexes through organic solvent (ICOS) method. Akahori Y, Kurosawa G, Sumitomo M, Morita M, Muramatsu C, Eguchi K, Tanaka M, Suzuki K, Sugiura M, Iba Y, Sugioka A, Kurosawa Y.Biochem Biophys Res Commun. 2009 Jan 23;378(4):832-5. 
  7. Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic. Kurosawa G, Akahori Y, Morita M, Sumitomo M, Sato N, Muramatsu C, Eguchi K, Matsuda K, Takasaki A, Tanaka M, Iba Y, Hamada-Tsutsumi S, Ukai Y, Shiraishi M, Suzuki K, Kurosawa M, Fujiyama S, Takahashi N, Kato R, Mizoguchi Y, Shamoto M, Tsuda H, Sugiura M, Hattori Y, Miyakawa S, Shiroki R, Hoshinaga K, Hayashi N, Sugioka A, Kurosawa Y. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7287-92. 
  8. Isolation of therapeutic human monoclonal antibodies for varicella-zoster virus and the effect of light chains on the neutralizing activity. Suzuki K, Akahori Y, Asano Y, Kurosawa Y, Shiraki K. J Med Virol. 2007 Jun;79(6):852-62. 
  9. Dendrodendritic electrical synapses between mammalian retinal ganglion cells. Hidaka S, Akahori Y, Kurosawa Y. J Neurosci. 2004 Nov 17;24(46):10553-67. 
  10. Isolation of human monoclonal antibodies that neutralize human rotavirus. Higo-Moriguchi K, Akahori Y, Iba Y, Kurosawa Y, Taniguchi K. J Virol. 2004 Apr;78(7):3325-32. Erratum in: J Virol. 2004 May;78(10):5534.