王 立楠

教員名

王 立楠 (わん りーなん) 特任助教

連絡先

〒514-8507 三重県津市江戸橋二丁目174番地
三重大学大学院医学系研究科病態解明医学講座
遺伝子・免疫細胞治療学
電話:059-231-5380/Fax:059-231-5397
Email:wln0201@doc.medic.mie-u.ac.jp

研究テーマ

腫瘍免疫、がんワクチン、CAR-細胞療法

プロフィール

中国大連出身、1993年大連医科大学卒業。
2001年留学生として来日。2006年三重大学大学院博士課程修了(医学博士)。
同年より遺伝子・免疫細胞治療学講座にて勤務。現在、腫瘍免疫、がんワクチン、キメラ抗原受容体(Chimeric Antigen Receptor : CAR)T細胞療法を主な専門分野として実験をしている。

所属学会

日本癌学会、日本がん免疫学会、日本免疫学会正会員

業績

  1. Yasushi Akahori, Linan Wang Motohiro Yoneyama, Motohiro Yoneyama, Motohiro Yoneyama, Takuma Kato, and Hiroshi Shiku.(2018)Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.Blood 132(11):1134-1145. doi: 10.1182/blood-2017-08-802926.

     

  2. Linan Wang, Ning Ma, Sachiko Okamoto, Yasunori Amaishi, Eiichi Sato, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, Takuma Kato and Hiroshi Shiku. (2016) Efficient Tumour Regression by Adoptively Transferred CEA-Specific CAR-T Cells Associated with Symptoms of Mild Cytokine Release Syndrome. Oncoimmunol ,25:5(9) e1211218.

     

  3. Hori, T., Kuribayashi, K., Saito, K., Wang, L., Torii, M., Uemoto, S., Kato, T. (2015) Alloantigen-specific CD4+ regulatory T cells induced in vivo by ultraviolet irradiation after alloantigen immunization require interleukin-10 for their induction and activation, and flexibly mediate bystander immunosuppression of allograft rejection. Transplant Immunology, 1-8.

     

  4. Hori, T., Kuribayashi, K., Saito, K., Wang, L., Torii, M., Uemoto, S., Iida, T., Yagi, S., Kato, T. (2015) Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity. World journal of transplantation 5, 11-8.

     

  5. Hori, T., Kuribayashi, K., Saito, K., Wang, L., Torii, M., Uemoto, S., Kato, T. (2014) Induction of alloantigen-specific CD4+ T regulatory Type 1 cells by alloantigen immunization and ultraviolet-B irradiation: a pilot study in murine transplantation models with skin and cardiac allografts. Ann Transplant 19, 519-36.

     

  6. Muraoka, D., Nishikawa, H., Noguchi, T., Wang, L., Harada, N., Sato, E., Luescher, I., Nakayama, E., Kato, T., Shiku, H. (2013) Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8(+) T cells. Vaccine 31, 2110-8.

     

  7. Kato, T., Tada-Oikawa, S., Wang, L., Murata, M., Kuribayashi, K. (2013) Endocrine disruptors found in food contaminants enhance allergic sensitization through an oxidative stress that promotes the development of allergic airway inflammation. Toxicology and Applied Pharmacology 273, 10-18.

     

  8. Noguchi, T., Kato, T., Wang, L., Maeda, Y., Ikeda, H., Sato, E., Knuth, A., Gnjatic, S., Ritter, G., Sakaguchi, S., Old, L. J., Shiku, H., Nishikawa, H. (2012) Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy. Cancer Research 72, 1672-1682.

     

  9. Shirakura, Y., Mizuno, Y., Wang, L., Imai, N., Amaike, C., Sato, E., Ito, M., Nukaya, I., Mineno, J., Takesako, K., Ikeda, H., Shiku, H. (2012) T-cell receptor ene thrapy targeting melanom-associated antigen-A4 inhibits human tumor growht in non-obese diabetic/SCID/gammanull mice. Cancer Science 103:7-25.

     

  10. Hori, T., Uemoto, S., Chen, F., Baine, A.-M., Gardner, L., Hata, T., Kuribayashi, K., Kato, T., Saito, K., Wang, L., Torii, M., Endo, K., Jobara, K., Sulistiono, B., Nguyen, J. H. (2012) Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9. Ann Gastroenterol 25, 345.

     

  11. Toda, M., Wang, L., Ogura, S., Torii, M., Kurachi, M., Kakimi, K., Nishikawa, H., Matsushima, K., Shiku, H., Kuribayashi, K., Kato, T. (2011) UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses. International journal of cancer 129, 1126-36.

     

  12. Kato, T. and Wang, L. (2011) UV-Induced Immune Suppression that Promotes Skin Cancer Development and Progression.

     

  13. Hori, T., Kaido, T., Oike, F., Ogura, Y., Ogawa, K., Yonekawa, Y., Hata, K., Kawaguchi, Y., Ueda, M., Mori, A., Segawa, H., Yurugi, K., Takada, Y., Egawa, H., Yoshizawa, A., Kato, T., Saito, K., Wang, L., Torii, M., Chen, F., Baine, A.-M. T., Gardner, L. B., Uemoto, S. (2011) Thrombotic microangiopathy-like disorder after living-donor liver transplantation: A single-center experience in Japan. World journal of gastroenterology : WJG 17, 1848-57.

     

  14.  Tsuda, K., Yamanaka, K., Wang, L., Miyahara, Y., Akeda, T., Nakanishi, T., Kitagawa, H., Kadeda, M., Kurokawa, I., Shiku, H., Gabazza, EC., Mizutani, H. (2011) Intratumoral injection of propionibacteriu acness suppresses malignant melanoma by enhancing Th1 immune responses. PLoS One 6:e29020.

     

  15. Wang, L., Saito, K., Toda, M., Hori, T., Torii, M., Ma, N., Katayama, N., Shiku, H., Kuribayashi, K., Kato, T. (2010) UV irradiation after immunization induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10. Immunobiology 215, 124-32.

     

  16. Torii, M., Wang, L., Ma, N., Saito, K., Hori, T., Sato-Ueshima, M., Koyama, Y., Nishikawa, H., Katayama, N., Mizoguchi, A., Shiku, H., Yodoi, J., Kuribayashi, K., Kato, T. (2010) Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation. European Journal of Immunology 40, 787-96.

     

  17. Muraoka, D., Kato, T., Wang, L., Maeda, Y., Noguchi, T., Harada, N., Takeda, K., Yagita, H., Guillaume, P., Luescher, I., Old, L. J., Shiku, H., Nishikawa, H. (2010) Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells. Journal of immunology (Baltimore, Md : 1950) 185, 3768-76.

     

  18. Mitsui, J., Nishikawa, H., Muraoka, D., Wang, L., Noguchi, T., Sato, E., Kondo, S., Allison, J. P., Sakaguchi, S., Old, L. J., Kato, T., Shiku, H. (2010) Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. Clinical cancer research : an official journal of the American Association for Cancer Research 16, 2781-91.

     

  19. Hori, T., Nguyen, J. H., Zhao, X., Ogura, Y., Hata, T., Yagi, S., Chen, F., Baine, A.-M. T., Ohashi, N., Eckman, C. B., Herdt, A. R., Egawa, H., Takada, Y., Oike, F., Sakamoto, S., Kasahara, M., Ogawa, K., Hata, K., Iida, T., Yonekawa, Y., Sibulesky, L., Kuribayashi, K., Kato, T., Saito, K., Wang, L., Torii, M., Sahara, N., Kamo, N., Sahara, T., Yasutomi, M., Uemoto, S. (2010) Comprehensive and innovative techniques for liver transplantation in rats: a surgical guide. World journal of gastroenterology : WJG 16, 3120-32.

     

  20. Imai N, Ikeda H, Tawara I, Wang, L, , Nishikawa H, Kato T, Shiku H. (2009)Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression. Cancer Science 100, 1317-25

     

  21. Wang L, Toda M, Saito K, Hori T, Horii T, Shiku H, Kuribayashi K, Kato T. (2008) Post-immune UV irradiation induces Tr1-like regulatory T cells that suppress humoral immune responses. International immunology 20 (1) : 57-70.